The whole point of Pentex is to provide a crossover antagonist
And if we're doing "myWoD"
myWoD Main Splat is mage
-Traditions, Technocracy, Marauders, and Nephandi each have part of the puzzle regarding the truth about reality.
Traditions understand that belief, will, and imagination define reality. On at least a subconscious level. Actually, all mages understand this on a subconscious level, but the Trads are the ones who can act on it. Such blatant force of will is why "backlash" has always been a risk for the Tradition mage
Technocrats based their Willworking off of Cosmological constants and extrapolated from there. That's why Technomagic always has some advantage when it comes to getting shit under the radar. This results in their inflexibility when it comes to improvisation.
Marauders "understand" the true nature of Avatars and Ascension better than anyone else. In fact, they suffer from too much perspective.
Nephandi have an edge when it comes to cosmology. They understand that the universe has no inherent meaning, but rather than create one for themselves they damn everything. They'd rather curse the darkness than strike a match.
In the case of Vampires, the Caine Story is basically true, but the specifics are not what people think.
Werewolves are so close, yet so far. Their way of thinking causes them to anthropormorphize everything, even when there's nothing there. For instance, while there are a whole lot of Jhor-tainted spirits out there, the Wyrm is not a discrete entity.
Wraiths exist, but the sixth great maelstrom has drastically culled the numbers of both Wraith and Specter. Surviving wraiths seem to be stronger than before, but their "societies" are mostly shambles beyond repair.
Changelings are as-written in C20, but the Prodigal theory is bullshit.
Hunters are Cats-paws of a variety of different forces, as the messengers actually aren't all the same thing.