I'm going to be running a Fallout themed game set in southern California, 20 years before New Vegas. Dump all your quest ideas and character art, I'll be doing the same.
Fallout Inspiration Thread
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Only idea I got is a quest that involves the scouts for the NCR and Legion. Maybe give the PCs a chance to run into them and either help or hinder them in some way.
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A small group of NCR rangers have started scouting out possible settlement locations, and have set up a hideout in an old firewatch tower in a national park? Sounds cool as fuck.
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I've actually played in games in that sort of setting. Google some places that are in the area on maps, then take a look around on street level. Now imagine that post-apoc and let it inspire you.
For example, check out Palm Gardens NV. First thing that comes to my mind is some sort of walled community.
Read up on the real world locations in the area you are running, then throw it in the 50's machine and give it an apocalypse paint job
A side quest could be someone got exposed to the same sort of FEV Harold from fallout 1 got exposed to. But instead of growing a tree, nothing happens. He hires the PCs to figure out his mutation.