Can you fit the Nonstandard Hybrids?

We all know D&D's classic halfbreeds, the half-elf and the half-orc. Yet, they're not the only ones. Across the editions and the settings, we've seen many different hybrids, from half-dwarves and half-gnomes to elf-orcs, dwarf-orcs, and elf-halflings.

So, I wanted to know; can you envision ways to fit half-breeds and crossbreeds who aren't the standard human/elf and human/orc mix into your campaign?

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it's legitimate theme for particular kind of ERP

I refluffed half-orcs as pigmen, who were created by fiends to rape and pillage the world, able to propagate their race only by mating with females of other races, since they were a male-only race. However they would go on to be defeated and demoralized and forced to live a common farming life. Their raider nature lives on as their tendency to join mercenary bands that allow them to build up a foundation of wealth that lets them provide an impressive dowry for their wife's father.

You make them sterile or have low fertility so they are rare and uncommon. In exchange, they get advantages like being smarter and stronger than both parents or something. Like mules. Some kingdoms may even force slaves to breed sterile, but superior off-spring for specific tasks.

I don't run any as hybrids.

Most half-things are out of my setting. Half-elves can happen only through magic, and elves are so isolationist that none would have children with a human, even less with other races. Half-orcs exist because orcs were made from humans, but they're present only in orc society.
Aasimar, tieflings and other such hybrids are a thing, thoguh rare, but not because "my father fucked a succubus/angel" reasons. Mortals can be affected by the essence and energies from other planes and their native creatures, sometimes said energies permeate their bodies and can be transmited to their offspring. A bit like how sorcerers work.
Other kinds of hybrids can exist because a wizard did it, I guess.

Do you ever have any that get disadvantages of both? Just shit on by life in general?

sometimes you wouldn't believe what species can be cross-compatible

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>can you envision ways to fit half-breeds and crossbreeds who aren't the standard human/elf and human/orc mix into your campaign?
Short yes
Long, yes of course, because I have AN IMAGINATION