I'm curious. What setting has done a decent, if not novel, take on vampires? Fantasy, futuristic, contemporary.... anything's fine. Personally, I only know about World of Darkness stuff, and very little of it, and Strahd from Ravenloft.
Vampires
Cooper Adams
Benjamin Flores
Bump.
Tyler Gray
Vampire the Masquerade is pretty much the gold standard. Just dial back to the 2nd Ed players guide and don't use any supplements at all.
Henry Martin
I really like the weird mosquito-themed vampires of Darkest Dungeon.
Landon Thompson
Star Wars
Caleb Edwards
WHF vampire counts are pretty neat, although not that unique.
Camden King
Just use V20.
Eli Sanchez
You know what? I unironically agree. Nihilus had a very real 'alien' quality to his thinking that made his Force-Vampire nature more like an eldritch abomination that your typically "so tortured but sexy" vampires.
Vampires need to be horrifying.
Luke Garcia
WoD was heavily influenced late 80s early 90s vampire movies and novels, but mostly by the works of Anne Rice, so do yourself a favor and at least watch the first movie, the one with brad pitt and banderas and child kirsten dunst
Moive The Lost Boys was also the basis of Brujah
Xavier King
If you cannot fathom sexuality as a horrifying tool for predation you're not experienced enough.