I would post the picture of the T-Rex with Jeff Goldblum's face on it, but I can't find it.
What's the weirdest shit you've ever had to fight Veeky Forums?
Oliver Walker
Evan Nelson
A fifty-foot squirrel which nearly killed the party. It shot lightning from its mouth
Asher Garcia
...
Robert Ward
Your magical realm called and has advised that you seek a therapist.
Lucas Perez
There was another where they fought giant grotesque babies piloted by intelligent regular-sized babies.
Basically, I would improvise scenarios based on a few idea generators and tables. The players were sent to different dimensions to do the dirty work of a vastly powerful wizard.