In what do I run high-flying action-adventure?

OP do you have a larger version of the image

Sadly, no.

GURPS has plenty of it, as cinematic or realistic-autistic as you want.

How about Spirit of the Century?

You are an idiot and all of that is elfgame low fantasy.

Run D&D 5e and go away.

For fear of the consequences I won't suggest GURPS, though I will say it's what I'd use. Either way, Mutants and Masterminds might work for you.

Everything I've heard about LotW made me think it was retarded.

There's stats for Cthulhu too. Everything has stats these days, so the PCs can kill them and take their stuff. I'm amazed the faggots at WotC haven't statted out the Lady of Pain, though that would require them to give a shit about something other than Forgotten Realms.

Feng Shui? Not exactly setting agnostic, but there's tons of archetypes and the setting is 'time travel shenanigans', so you can do pretty much whatever with the rules provided.

RISUS.

You lil' bitch.