Fate needs to be a theme, even a stat. IT affects all, even the gods. Hubris is defying your fate. You can take notes of Miura's Berserk in this. Guts is a greek hero, beneath the aesthetic.
Attempts to reach the level of gods makes gods aware of you. This may the worst thing ever.
Snakewomen want to have sex with you
Hydra is A dragon, not a type of lesser monster.
Stay away from Typhon and Achilles.
Try to judge a singing contest between mountains sometime.
The paradise is north, perhaps west. You can reach it by foot, they say.
Galleys rowed by poor freemen.
Slaves.
Heroes are ones that challenge the gods, attempt to make their own fate, not nice or good people. And unless one god patronizes them, they fail. They may fail even with a god's protection. Remember that both Heracles and Midas were heroes.
Everything has a antromorphic personification, even the river east after a day's travel. Every god has plenty of daughters or sons that are representations of things associated with their divine domain.
You can have a race of half-bear giants if you wish.
One of the PCs makes part of a mystery cult, and that explains why he's has wizard powers drawn from ancient texts from wacky eastern or egyptian lands where they do everything different.
Bronze automatons are a thing. Artificers capable of making those may be your only source of magic items that aren't gifts or pieces ripped off monsters that have divine parentage.
The Gods pretty much follow the idea of might makes right and zoophilia isn't a thing.
That is what came up to my mind.