40k vtm

Pretty well, but they would have to be careful to avoid coming to the attention of the inquisition. They would be considered either mutants or some form of daemon host, and the Inquisition would seek to purge them.

Whether they ARE mutants or daemon hosts would determine how subject to chaos corruption they are. I would make them the latter so they don't have to worry about any further daemonic possession or warp corruption. A lot would depend on whether you treat their powers as unencumbered warp fuckery or as analogous to standard psychic powers which risk the perils of the warp. A Ventrue who can't hypnotize his meals without worrying about tearing a hole in reality would not last very long.

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yeah, but turning them into a 40k thing isn't the point. what if they work according to VtM metaphysics?
Disciplines aren't warp stuff, they just work because of God's curse on Caine? Like you get infernalist vampires (the baali etc) that might fall to chaos, but most vamps are pretty anti-demon.

Typically, I don't like to bring factions into a setting without aligning them with said setting metaphysically, i.e. having them play by the setting's rules. That said if you want VtM vampires with VtM rules in a 40K setting, then that would just make them more secure since warp corruption from power use wouldn't be an issue. Hell, they'd probably be recruited by radical inquisitors since their powers can be used without risk.

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>Same goes for Caine.
Who knows. He's supposed to be the first murderer, so he technically created the Drach'nyen.

He may be some kind of greater daemon of Chaos Undivided. Perharps the assamites were right all along

So, vamps are cursed by the Emperor? They're not going to last much...

Caine is, canonically, several orders of magnitude stronger than W40K gods. He just doesn't give a fuck most of the time, playing vagrant/shut-in/cabbie.
Tremere, Tzimisce, Lasombra anties are as strong or stronger than chaos gods. Saulot would be pretty even with Emps if not for his martyr complex.
The rest of antediluvians are about as diverse in power level as greater demons and lesser gods.
Ventrue is shit.
Augie is dogshit.

Great, hive worlds would be the most perfect environment imaginable for them.

Emperor is but a human, great that he is. Even then he doesn't match your bog-standard average MtA PC.

The Emperor is an analogue of Christ, but the analogue of the God of Abraham (and Caine) is actually Chaos Undivided.

Caine would be a high powered Daemon Prince of Chaos Undivided.

>Caine is, canonically, several orders of magnitude stronger than W40K gods.

Either I don't know how strong Caine is, or you don't know how strong the Chaos gods are, because this claim seems absurd.

Ventrue takes over a planet as it beloved rightful governor, and manages it better than any mortal could.
Toreador's exposed and dusted or becomes a daemon prince of Slaanesh.
Brujah rages, exposed and dusted or pressganged in blood angels.
Gangrel signs up with the Space Yiffs.
Tzimisce usurps Hivemind and controls entirety of the tyranid race, kills Nurgle, becomes the new chaos god and wrestles domain of mutations from Tzeench.
Nossie chills in the underhive.
Nobody still knows whereto Lasombra buggered off or what is he up to.
Tremere rules Imperium in the century or so. In two, he's God. In three, he's the sole God, if not usurped by Tzimisce.