Realistically how close are we to making superhumans using CRISPR? How about changing merely cosmetic features like hair color?
Realistically how close are we to making superhumans using CRISPR...
Jackson Carter
Isaac Hall
My sources say no
Julian Carter
what a shame
Hudson Gray
Ask the chinese, they the ones who are working on it right now.
Oliver Lewis
We are doing nothing with it and will do nothing for the next thirty years minimum.
China and Japon is where you should look at.
Learn one of the languages and go there if you want to do anything with it.
Charles Gray
Not close at all. CRISPR is a wonderful tool for knocking things out and it makes site directed replacement pretty easy, but ultimately the limiting factor is our knowledge.
First we would have to know HOW to make superhumans, and that's knowledge we lack. It's like saying, "I got a really cool wrench today, that means I can turn my early 90s shitmobile into a ferrari right". Having the tool is worthless if you don't know how to apply it.
Jaxson Long
Knowledge that merely suggesting we should gather being career-ending in the west.
The knowledge you talk about is basically an admission that subhumans are inferior beasts fit only for slaughter.
It'll never happen.
Again, any one worth he's salt wanting to use CRISPR to advance Humanity need to fuck off to either China or Japon.
This is not a joke. The languages takes two years to learn from a latin background. Start NOW.
Jayden Murphy
Apparently this topic is getting posted here a lot now because of a recent YouTube "science" video on the CRISPR-Cas9 nuclease system. Don't let that/anyone fool you. CRISPR was certainly an impressive development, but its utility now is mainly as a stepping stone to more advanced, accurate and controlled methods using designer proteins. I applied and interviewed at several labs working on genome editing; all of them are using newer, novel methods.
Jayden Morales
>newer, novel methods
Like what? Not being sarcastic, I am really curious, I had some background in that area but I have been disconnected for a long time.
Luis Allen
We have hair dye though.
Leo Wright
The bleeding-edge of gene editing is using vectors to deliver designer proteins (nucleases) that interact with specific gene sequences, rather than something like CRISPR which makes use of just one exonuclease but can "recognize" different gene sequences.
Basically: CRISPR receives an input sequence to recognize and cut out using a protein called Cas9. The future, at least what seems to be the direction the field is headed in, is designing a protein that doesn't need an input signal, but rather reacts selectively with sequences of interest. The idea here too is that nuclease function is more specific, and sequence insertion is theoretically easier as well. A large enough protein could cut the gene out and then poise the genetic polymer for gene insertion in one fell-swoop.
Additionally, where CRISPR and other prokaryotic gene interference methods fall short is that there is a large disparity in how eukaryotes and prokaryotes handle genetic information -- the former being more complex and making use of all sorts of post-transcriptional/post-translational modification. CRISPR can teach us a lot mechanistically and even be applied in some cases, but its potential is limited for human applications.
Justin Lopez
Translation : the red tape and muh ethics fuck us in the ass.
China don't give a fuck if the few dozens batchs come out as abominations.
They'll still let you do it.
Have fun playing with mouses and shit. Real inspiring work.
Mason Lewis
>Cas9
I have heard about other variants, and doing a little research I have found that you could use Cpf1 as a replacement, and it's supposed to be more efficient and use less resources than the Cas9 variant.
phys.org
nature.com
Brayden Lewis
Just happened youtu.be
Jack Cox
Yeah I've studied several variants as well, some of the same issues I mentioned still stand, but I'll read up on these links. Thanks.
Matthew Miller
kek
Caleb Jackson
Check out the Zhang lab's work. those guys are really where its at, they just published a 65 kbp deletion. SIXTY FIVE FUCKING KILO BASES. bananas.
t. A biochem phd
Cooper Gonzalez
>they just published a 65 kbp deletion. SIXTY FIVE FUCKING KILO BASES. bananas.
I mean, it's just a matter of causing two double-strand breaks 65 kb apart...
John Jones
Trust me, its a bitch. You have to get the homologous arms just right. Admittedly, its not as impressive as the 5kb insertion they managed, but hey, big numbers tend to sell to people.
65 kb is enough to happily delete a whole group of splice variants.
5kb is enough to insert a new gene. really when you get to whole genes, you can just use multiple plasmids, and insert as many genes as you want.
basically next stage is to get AA viruses down, and we can actually look at curing human diseases in adults. I will be the happiest man when such a thing can be done.
Mason Wood
There's no way that the US military isn't already experimenting with this shit. Do you think they would let China get an advantage on the supersoldier front?
Leo Torres
That's nice, the us is testing on dozens to thousand of embryos.
Meanwhile, since it's fucking legal in fucking China, there's no fucking limit on the number of experiments you can be running.
And there's another one big fucking problem here : commercialisation, and implementation in the general population.
As soon as a good set of genes to reliably produce genuises is found, China will be able to implement it in ALL its population ( well, future population ), because the legal framework is already here.
Meanwhile, in christcucks west ( well, soon to be islamshit, which for genetic engineering is the same, probably worse since they're hardcore on the "body is a temple" shit ), you'd have to fight tooth and nails to have the random joe be able to PAY for it, let alone force it on them ( i'd personally push any chinese official that come my way to push for forcing it tbf ).
So whatever happen, the west will at minimum, IN THE BEST CONDITIONS lag from one to three generation of enhanced humans behind China and Japon maybe ( the fucks are getting too influenced by the west for my taste ).
You seriously think China would need more than even one generation to put to good use their tens of millions of 160+IQ fagglets ?