Drugs

what drugs don't have a net negative impact on cognitive functioning in the brain from long term semiregular use?

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youtube.com/watch?v=1Zcrb1ff1xs
en.wikipedia.org/wiki/Creutzfeldt–Jakob_disease
search.proquest.com/openview/435caf94bf3800ed6ce1d8219e29249f/1?pq-origsite=gscholar&cbl=44265
ncbi.nlm.nih.gov/pmc/articles/PMC5509699/
scholarcommons.usf.edu/etd/166/
psychologytoday.com/sites/default/files/attachments/47337/the-ten-lessons-psychedelic-psychotherapy-rediscovered.pdf
sciencedirect.com/science/article/pii/S0140673610614626
nature.com/neuro/journal/v17/n2/full/nn.3623.html?foxtrotcallback=true
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I've heard contradictory things about the after-effects of stimulants, that they give brain damage and that they actually help develop the brain to be better functioning overall. Which is true? What drugs are safe to use as far as the mind goes? Psychedelics are good or bad?

amphetamines (Paul Erdős used them)
caffeine (Mathematicians turn coffee into theorems)
micro-dosing psychs (probably still bad if predisposition to schizophrenia)

Anything can be bad if you use too much or use for too long.

The artificial reward of the drug to the brain can mess with dopamine (responsible for learning).

It might be wise to put-off using them until your brain is fully developed (mid to late twenties)

If you are concerned/uncertain about safety, it's probably better to err on the side of caution and not do them.

>Anything can be bad if you use too much or use for too long
Paul Erdos used amph his whole life. What does Veeky Forums think of amphetamine's effects on the brain?

Unfortunately I only have access to ritalin anyway

Aspirin.

I'd imagine long term, (very) minor brain damage and repair could be like simulated annealing for your brain cells.

ME
TH

Use a wide variety of different drugs that work on different parts of the brain.

lol

youtube.com/watch?v=1Zcrb1ff1xs

Anything is poisonous in large enough quantities. Inversely, everything is safe in small enough quantities.

Krokodil

bew whoop

Been taking amphetamines and ritalin for about 10 years, switching between them when I need to travel to a country where one is illegal or just want a change due to tolerance or whatever.
I don't think the whole burning out your pleasure receptors is real, at least not at therapeutic doses.
My brain did break eventually however and now I need to take antipsychotics daily.
Might be unrelated though since I've got a family history of insanity.

>I don't now how to refute this logic that goes against my emotion-based beliefs

Alcohol

The>>>was>>>logical
>>>post>>>not>>>>>

fuck off druggies

Took vyvanse for the first time today, and it's literally the most focused I've been in years. Am I retarded? I've been getting this feeling lately, that I've become dumber and dumber as I get older (I'm 23). After talking vyvanse, I put in the most honest 8 hours of work in the past 5 years. I could focus properly, and when my mind would start to wander, I could control it easily. Am I just a brainlet?

Prions: not even once

en.wikipedia.org/wiki/Creutzfeldt–Jakob_disease

>what drugs don't have a net negative impact on cognitive functioning in the brain from long term semiregular use?

Most of them.

strychnine

Tryptamines and ß-carbolines have been shown to increase neuroplasticity, neurogenesis and regulate neurotransmitters, helping to treat psychological disorders like depression, anxiety, PTSD and addictions.

There is known (or a very very high) LD50 for most of these substances

search.proquest.com/openview/435caf94bf3800ed6ce1d8219e29249f/1?pq-origsite=gscholar&cbl=44265

ncbi.nlm.nih.gov/pmc/articles/PMC5509699/

scholarcommons.usf.edu/etd/166/

psychologytoday.com/sites/default/files/attachments/47337/the-ten-lessons-psychedelic-psychotherapy-rediscovered.pdf

Tldr what are those links senpai

>heroin
>harm to users
DROPPED

Opiates cause addiction, constipation, and MAYBE hearing loss, that's it.

Its the user that causes self-harm, not the drug.

It's called ADD. Get that checked out.

>its the users not the drugs
>implying that the drug was not a root cause

Top fucking kek. You are retarded my son

>food causes obesity

>not realizing food and water is a required necessity to maintain proper bodily functions
>not realizing such drugs that cause self of societal harm are due to the drug itself as without its presence nout would occur on account how it influences your thoughts
>yes its partly due to the user but not a root cause

Just one AIDS virus can fuck your life up (but generally your argement is correct)

kill yourself my man

The addiction is pretty bad though
I think that's the most important factor for that rating
Also there is the danger of respiratory depression
David Nutt is educated in psychiatry, neurology and pharmacology and got fired from his position as British chairman of the Advisory Council on the Misuse of Drugs (ACMD) when he published this evidence based research and didn't support official illegal "drugs bad/ legal drugs good" position

here is the study (avoid paywall with sci-hub dot biz):
sciencedirect.com/science/article/pii/S0140673610614626

>research about therapeutic potential of psychedelics and their neurophysiology
>psychedelic psychotherapy is very effective
>psychedelics help neurons make new connections and break habits (disorders, addictions etc.)

yeah the root cause of doing heroin is heroin

well now wait a darn minute

>take a substance that enhances/inhibits your cognitive function by affecting your brain chemistry and forcing your brain to seek chemical balance
>expect it not to have any kind of negative impact
This is why crashes hangovers and withdrawals are a thing

Addiction is not harm like brain damage is harm

Acute addiction is completely reversable

Yeah, heroin in sub lethal doses is non toxic
The addiction is influencing the consumers life though and messes with your endorphine and dopamine system.
Harm =/= physiological damage

>If you lack self-control with food, it's your fault
>If you lack self-control with drugs, you dindu nuffin mang

>implying obesity doesn't cause personal and societal harm
>implying the lack of a particular drug prevents other addictive behavior
>implying heroin addicts will stop being prone to addiction if all heroin in the world suddenly disappeared

/pol/ teir response

hilariously misguided. dont attempt factual statements after reading a few things and thinking you are informed. You ARE /pol/ teir, exaggerating and trying to spook the reader into submitting to your beliefs.

Exercise messes with your endorphine and dopamine system

The drug does not influence the consumers life more than they let it, they would be living like that with or without the drug.

To say a heroin user digs in his arm fucking his veins with a needle is because of heroin is clearly an opinion held by some PHD far away in an office somewhere, speculating after reading the farts of someone just like him. It is not science.

Ecstasy/Molly
t. Mentally Ill

>One AIDS virus
That multiplies into many

Amphetamines
Psychedelics

Regular opiate consumption overstimulate your dopamine receptors, making it harder to experience satisfaction through over stimuli; for example exercise, eating or sex.

This influences your habits and in users that have problems to begin with, are likely to withdraw from social life and isolate themselves and not pursue more healthy methods of getting that dopamine.

Once habituation is there, withdrawal becomes pretty nasty and painful, making it hard to stop.

The stronger an opiate is, the easier it is to lose control over your consumption habits.

For example Fentanyl > Diacetylmorphin > Morphin > Kratom

All are opiates, but Fentanyl is the most dangerous because it is the strongest, can result in a stronger addiction and withdrawal symptoms and is easier to OD.

Also I think the study considers reality of users: black market, associated criminality etc.

If it would be legal the rating would probably drop.

What is Veeky Forums's opinion on nootropics i.e. the racetam family?

>lets assume there exists no drug such as one aforementioned of start of debate
>there exists not trace of such and all alike drugs
>assume everything else equal
>no more self harm due to drug because no drug

Cheg mage, son

90%+ of that is opinion. coupled with the reddit style i dont feel it deserves any post greater than this.

why tf is Veeky Forums a drug board

Yeah, that's opinion based on talking with addicts and knowledge of relevant research.

So what is your opinion and what do you base it on?

why do you parrot malformed opinions of facts, as facts

Everything you said should've started with "I think", except 3 and 1 before the comma

Everything you contributed to the conversation is assumptions about what boards and websites I visit.

So what is your point of view on the issue?

PS: here is how the study evaluates harm to self and others

neurochemistry is fun

But that doesn't address the addictive personality or situations in life that drive people to addiction. You're just opening the doors to replacing one addiction with another.

Look at the affects porn or sugar have on the brain; they're very similar to that of many recreational drugs. They can both be very addictive, but aren't necessarily harmful if they're enjoyed in moderation.

>/find 'nicotine'
>'no results found'

Nicotine has neuroprotective effects. Just chew nicotine gum and don't smoke because obviously smoking is bad for you.

nicotine replacement stuff is way too expensive.

Nicotine isn't exactly great on its own

we're talking about non-biological substances here

How about smoking tobacco from a pipe? You absorb less nicotine but you're not burning up your lungs. And organic tobacco won't have the asbestos or BPA you can find in cigarettes.

How detrimental are passing out completely and having black outs (alcohol) for your brain?

>Nicotine isn't exactly great on its own
As in: Nicotine isn't a pleasurable substance alone, or nicotine isn't a healthy substance?

>You absorb less nicotine but you're not burning up your lungs. And organic tobacco won't have the asbestos or BPA you can find in cigarettes.
Surely the tobacco itself is the worst, most dangerous part of smoking. The asbestos, BPA and nicotine are negligible in comparison. Smoking from a pipe will ruin your teeth, give you a hairy tongue and even kill you faster than any other avoidable death causing substance.

You have a meth user, she picks at her face until there are scabs, and picks those as well.
She applies makeup to cover up the damage, but resumes picking a few minutes later, so she re-applies makeup.

Here you have physical, psychological and likely social harm that result from this behavior. (That likely would be labled drug related)

She goes to rehab, stops using meth, and stops picking.

Years later (sober from drugs) she has an anxiety attack, forms an anxiety condition and starts picking at her face until there are scabs.


How can you say the picking she was doing on meth was drug-related, when it could be from an underlying condition.


My point is you cant say social, psychological, or physical harm is drug related, with certainty, without a full, completely honest history of the subject. Which is often hard to do, because many drugs cause distortion to memory.


it's a crap-shoot catchall to start labeling drug-related harm on anything but a biological level. we do not know enough

Invariably when you smoke tobacco in any way you're sucking burnt plant matter into your lungs. This is where the majority of carcinogens and tar comes from.
The only reason potheads don't get the same significant rates of lung and throat cancer is because they smoke significant;y less often.

>Surely the tobacco itself is the worst, most dangerous part of smoking

It's not. It's the fact that you're taking it into your lungs.

Is there any proven safe way of enjoying tobacco? - e.g. snus, chewing tobacco, dipping tobacco. As far as I'm aware you're wrong because the tobacco itself contains carcinogens. Chewing tobacco is linked to oral cancer, for example.

The fact that a famous mathematician did a particular drug doesn't make it harmless. These guys are starting off with a lot of brain power and can afford to lose a bit and still be great.

Paul Erdos did amphetamines, sure. Plenty of other mathematicians were alcoholics. Draw your own conclusion

there was a thread a while ago about this on Veeky Forums, but the jist of it was that there are unflavored varieties of vegetable glycerin based e-liquids that can be applied topically in a manner not dissimilar to regular nicotine patches

Why

do

you

keep

doing

this?

You can smoke tobacco without taking it into your lungs.

As for chewing tobacco, it causes problems because people keep that shit in their mouths for 18 hours a day. Everything is going to cause problems under that circumstance. If people put it in their mouths for 2 minutes every 3 hours, it would be perfectly fine.

>only

This is sarcasm, right?

Coffee

>if I say something it must be true

Doesn't that stuff have to be present during childhood to get any diagnosis?

If you want to do drugs there's already something wrong with your brain lol

Nah that shit decreases learning in the hippocampus

Caffeine dependency basically removes any benefits of continual usage of caffeine, with dependency developing in a couple of weeks of daily usage. You basically get to the point where your dose of caffeine is required to function at the same levels as non-drinkers. It's best used as a slight performance enhancer on infrequent occasions (i.e. exams) if you're looking for any benefits from its use.

Not at all, chum. Tobacco contains carcinogens, there is no way to consume tobacco without doing some form of harm. Tobacco-specific nitrosamines are confirmed carcinogens. Saying there's ''less nicotine'' is a negligible detail.

Most studies actually show the opposite effect, when speaking in terms of infrequent consumption. Suffice to say, long-term caffeine ingestion can't have good effects on your learning. Infrequent doses, ie once every couple of week, would be beneficial if anything.

Reddit spacing retards think Veeky Forums is their safe space because we're all atheists.

I know it contains carcinogens, but is tobacco smoke really more dangerous than BPA? BPA significantly increases risk of cancer as well, but has the added harm of being a xenoestrogen that can fuck up your metabolism, fertility, lungs, and even dopaminergic system.

And by "less nicotine" I meant you would need to smoke more pipe tobacco to get the same amount of nicotine you would get from a cigarette, considering the membranes in your mouth and sinuses don't absorb nicotine as readily as your lungs do. My point was that smoking from a pipe is a less unhealthy way of getting nicotine into your system than cigarettes, if you can't afford nicotine gum or patches.

I will post however i want you stupid fag.

if it happens to end up spaced out, it's a plus that it triggers your autism

Stop

Doing

This

You

Piece

Of

Shit

You

are

not

on

reddit

if you want to absorb a shit load of nicotine, vaping will do it.

i used to smoke about 10g tobacco a day, unfiltered. switched to vaping, and now i go through about ~50mg per day, it only costs about ~$15 per month.

Dude,
chill
the fuck out

Behold the world's dumbest man

if you are going to refer to me use the proper pronouns, faggot

I don't care about reddit spacing but you just kinda strike me as a dumbass retard. Sorry

i am struggling to live with the statements you have made about me

I'm sorry I don't mean to offend, I just don't like your posting in this thread

sounds like it is in your best interest to get over it

you can't stop me

No. It's most common in children because children are naturally a little aloof, because they're kids. Thus parents like to assume that because they can't control their brat, (or if they aren't how the parent wants) they take them to the doctor. The doctor immediately agrees it's ADD/ADHD and prescribes a mildly expensive drug.

Parents keep paying, kid slowly loses his shit - if it's adderall, it's a medical amphetamine. Guess what that does to the brain of a developing child? Never the same.

Dimethyl Mercury.

So olney's lesion only been observed in lab animals? Never in humans?
Genuinely curious.
>Captcha: choose jaguars
>Two leopards, a cheetah and a black puma

>Government gets scared of drugs
>People can no longer do research on them openly
>Very important questions like "Can psychedelics be used to treat pre-existing mental conditions?" go unanswered
>Politicians kinda-sorta realize they fugged up and are finally starting to greenlight research into psychoactive drugs and their medical uses
>We're 50 years behind then we should be, all because a bunch of dumb-ass soccermoms had ANOTHER moral panic attack

THIS is why I'm such a strong advocate for libertarianism...

So you're saying I should take
1. A small line of coke
2. 1 mushroom
3. A single toke a speed

and

4. A can of Redbull

All at the same time? Sounds legit.

Actually it was more of a /pol/ tier anti beaner, blacks (cannabis) and hippies (psychedelics) agenda, combined with pseudochristian puritan morality, economic interests (fiber, pharmaceuticals...) and a lot of police sitting around without a job after alcohol prohibition proofed to be retarded.

The soccer moms were useful tools at best

But yes, we are embarrassingly far behind on research about this topic and the most extensive material is up to 60 years old (Hofman, Shulgin, Grof etc.) but it is getting back on track finally.

I like nicotine and puff on my friends vapes when I'm out but then I bought my own

After puffing on it a little per day after a week my lungs felt like shit and I got rid of it. I'm sure smoking and vaping for a long time you get normalized to feeling shitty lungs all the time and forget how breathing should be naturally

nature.com/neuro/journal/v17/n2/full/nn.3623.html?foxtrotcallback=true

Really makes my neurons fire

>a /pol/ tier anti beaner, blacks (cannabis) and hippies (psychedelics) agenda
conspiracy theory tier. Are you gonna start sperging about how prisons are a massive plot to keep blacks enslaved and crack was introduced by the FBI to destroy black families?