Also, are you on any antihistamines? Too much histamine signaling has been implicated in a variety of psychological illness, like anxiety disorders. Google that too.
If you shove suppositories up your ass...
Jack Brown
Kayden Cox
>magnesium
Tried it a million times.
Countless forms of it too.
Just gives me gut pain and stomach discomfort.
Vitamin C worked perfectly.
>Also, are you on any antihistamines?
No.
Kayden Scott
I'm just shotgunning at this point. Have you tried probiotics? Over an average of clinical trials, probiotic administration increased the number of weekly bowel movements by 1.3:
health.harvard.edu
At any rate, I hope you find a solution. That sounds miserable.
Luis Gray
>Have you tried probiotics?
Yes, holy shit countless times, countless strains.
Yes, prebiotics too.
They do absolutely nothing.
>At any rate, I hope you find a solution. That sounds miserable.
It's really bad.
Thanks though.
Andrew Smith
NOTE THAT IT WAS NEVER ONCE, EVER, MENTIONED ANYWHERE THAT VITAMIN C WAS ACTUALLY USED TO TREAT CONSTIPATION!
VITAMIN C
According to Up to Date which we use for our med education:
>Upper limit of intake of Vit C should not exceed 2,000 mg daily
Vitamin C dosage considerations:
>Kidneys
May have some impact in absorption so renal damage can affects absorption
>Liver
Plays no impact in removing Vitamin C from the circulation according to manufacturers.
>When should people take Vit C?
Malabsorption, use in conditions requiring an increased intake (eg burns, wound healing), dietary supplement, treatment of scurvy
>mechanism of absorption
Intestinal absoprtion is basically dependent on how much you take. Unabsorbed Vitamin C goes to the intestine where it is destroyed.
Julian Stewart
>NOTE THAT IT WAS NEVER ONCE, EVER, MENTIONED ANYWHERE THAT VITAMIN C WAS ACTUALLY USED TO TREAT CONSTIPATION!
But it works for constipation though.
Everyone knows this.
It worked for my constipation for 6 months.
>Unabsorbed Vitamin C goes to the intestine where it is destroyed.
It goes to the intestines where it increases water retention and has a strong laxative effect.
Thomas Foster
*
-CONSTIPATION-
Treatment:
>Dietary Fibre/bulk-forming laxatives
For example psyllium or methylcellulose taken with water. Other examples include psyllium seed (eg, Metamucil), methylcellulose (eg, Citrucel), calcium polycarbophil (eg, FiberCon), and wheat dextrin (eg, Benefiber).
Prunes worked according to one study.
20 to 35 g/day fibre recommended, you can add 2-6 tablespoons of bran followed by one glass of water to hit that.
IF BULK FORMING LAXATIVES DON'T WORK:
Then trying non bulk forming laxatives:
>Surfactants
Not much evidence supporting this as a good treatment.
>Osmotic agents
Increases water in the intestine, may have some heart/kidney issues.
Examples: PEG – PEG electrolyte solutions (eg, GoLYTELY) and powdered preparations (eg, MiraLAX). One study found that PEG was effective
Synthetic disaccharides – Lactulose. Basically these are sugars that don't get digested and so sit in the intestine and attract the water to them.
Saline - These are your magnesiums. Magnesiums attract water to them in your intestine. Kidney failure may be a complication.
>Stimulants
eg Dulcolax. Evidence that it works in a trial. Taking too much of these can can caused reduced potassium levels, loss of protein through intestine and too much salt in the body. According to Up to Date using these drugs won't cause your intestine to stop functioning normally if you use it for long periods.
Juan Campbell
Vit C is generally harmless to take according to one of our tutors (a GP) and if there's too much in the blood it can also come out in the urine.
Most constipation treatments except the ones for severe constipation attempt to attract water and retain it there like you said.
Severe constipation treatments are basically liquifying the faeces (Suppositories), breaking the faeces up into little bits (Disimpaction).
Drug treatments can cause more intestinal fluid to be produced (eg Linaclotide), increase bowel movements (Plecanatide) or increase the concentration of the stuff (well, chloride) coming out of the intestine (Lubiprostone) to help attract waterr.
Cameron Fisher
Of the research articles I can find I came across one study relating vitamin C and constipation.
It's a pretty obscure/not especially respected journal apparently in Italian.
>[Rectal administration of sodium ascorbate in constipation]
ncbi.nlm.nih.gov
There's also a research study called 'High-dose intravenous vitamin C improves quality of life in cancer patients' that suggests that Vitamin C (but injected into the muscle and diluted with magnesium sulfate) as well as some vitamin c taken by mouth. After 4 weeks of treatment patients reported that their constipation had improved (p
Alexander Morales
Pharmacology database:
Apparently large quantities of Vitamin C can cause diarrhoea but too much can also cause some crystals to build up in the kidneys.
Vit C can also interact with some drugs (sometimes drugs can compete for receptors and reactions resulting in reduced effect and whatnot). Drugs for bipolar reduces Vitamin C levle.
Vitamin C can also be destroyed during storage and cooking.